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Dr. Yu's Publications
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Cui L, Jiang J, Wei L, Zhou X, Fraser JL, Snider BJ, Yu SP. Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats. Stem Cells 2008;26:1356-65.
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Hu X, Yu SP, Fraser JL, Lu Z, Ogle ME, Wang JA, Wei L. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg 2008;135:799-808.
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Li J, Lu Z, Li WL, Yu SP, Wei L. Cell death and proliferation in NF-kappaB p50 knockout mouse after cerebral ischemia. Brain Res 2008;1230:281-9.
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Li WL, Yu SP, Ogle ME, Ding XS, Wei L. Enhanced neurogenesis and cell migration following focal ischemia and peripheral stimulation in mice. Dev Neurobiol 2008;68:1474-86.
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Liu XB, Wang JA, Yu SP, Keogh CL, Wei L. Therapeutic strategy of erythropoietin in neurological disorders. CNS Neurol Disord Drug Targets 2008;7:227-34.
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Theus MH, Wei L, Cui L, Francis K, Hu X, Keogh C, Yu SP. In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain. Exp Neurol 2008;210:656-70.
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Wei JF, Wei L, Zhou X, Lu ZY, Francis K, Hu XY, Liu Y, Xiong WC, Zhang X, Banik NL, Zheng SS, Yu SP. Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility. J Cell Physiol 2008;217:544-57.
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Keogh CL, Yu SP, Wei L. The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats. J Pharmacol Exp Ther 2007;322:521-8.
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Li Y, Lu Z, Keogh CL, Yu SP, Wei L. Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice. J Cereb Blood Flow Metab 2007;27:1043-54.
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Takata T, Hood AY, Yu SP. Voltage-dependent and Src-mediated regulation of NMDA receptor single channel outward currents in cortical neurons. Cell Biochem Biophys 2007;47:257-70.
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Whitaker VR, Cui L, Miller S, Yu SP, Wei L. Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. J Cereb Blood Flow Metab 2007;27:57-68.
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Abdalah R, Wei L, Francis K, Yu SP. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett 2006;405:68-73.
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Lu ZY, Yu SP, Wei JF, Wei L. Age-related neural degeneration in nuclear-factor kappaB p50 knockout mice. Neuroscience 2006;139:965-78.
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Theus MH, Wei L, Francis K, Yu SP. Critical roles of Src family tyrosine kinases in excitatory neuronal differentiation of cultured embryonic stem cells. Exp Cell Res 2006;312:3096-107.
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Wei L, Han BH, Li Y, Keogh CL, Holtzman DM, Yu SP. Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats. J Pharmacol Exp Ther 2006;317:109-16.
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Wang XQ, Yu SP. Novel regulation of Na, K-ATPase by Src tyrosine kinases in cortical neurons. J Neurochem 2005;93:1515-23.
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Wei L, Cui L, Snider BJ, Rivkin M, Yu SS, Lee CS, Adams LD, Gottlieb DI, Johnson EM, Jr., Yu SP, Choi DW. Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. Neurobiol Dis 2005;19:183-93.
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Wei L, Keogh CL, Whitaker VR, Theus MH, Yu SP. Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke. Pathophysiology 2005;12:47-62.
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Yang A, Wang XQ, Sun CS, Wei L, Yu SP. Inhibitory effects of clofilium on membrane currents associated with Ca channels, NMDA receptor channels and Na+, K+-ATPase in cortical neurons. Pharmacology 2005;73:162-8.
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Sheline CT, Takata T, Ying H, Canzoniero LM, Yang A, Yu SP, Choi DW. Potassium attenuates zinc-induced death of cultured cortical astrocytes. Glia 2004;46:18-27.
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Wei L, Xiao AY, Jin C, Yang A, Lu ZY, Yu SP. Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and apoptosis in cortical neurons. Pflugers Arch 2004;448:325-34.
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Wei L, Ying DJ, Cui L, Langsdorf J, Yu SP. Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats. Brain Res 2004;1022:54-61.
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Ichinose T, Yu S, Wang XQ, Yu SP. Ca2+-independent, but voltage- and activity-dependent regulation of the NMDA receptor outward K+ current in mouse cortical neurons. J Physiol 2003;551:403-17.
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Wang XQ, Xiao AY, Sheline C, Hyrc K, Yang A, Goldberg MP, Choi DW, Yu SP. Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. J Cell Sci 2003;116:2099-110.
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Wang XQ, Xiao AY, Yang A, LaRose L, Wei L, Yu SP. Block of Na+,K+-ATPase and induction of hybrid death by 4-aminopyridine in cultured cortical neurons. J Pharmacol Exp Ther 2003;305:502-6.
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Wei L, Yu SP, Gottron F, Snider BJ, Zipfel GJ, Choi DW. Potassium channel blockers attenuate hypoxia- and ischemia-induced neuronal death in vitro and in vivo. Stroke 2003;34:1281-6.
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Yu SP. Na(+), K(+)-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death. Biochem Pharmacol 2003;66:1601-9.
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Yu SP. Regulation and critical role of potassium homeostasis in apoptosis. Prog Neurobiol 2003;70:363-86.
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Heidinger V, Manzerra P, Wang XQ, Strasser U, Yu SP, Choi DW, Behrens MM. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci 2002;22:5452-61.
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Xia S, Lampe PA, Deshmukh M, Yang A, Brown BS, Rothman SM, Johnson EM, Jr., Yu SP. Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation. J Neurosci 2002;22:114-22.
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Xiao AY, Wang XQ, Yang A, Yu SP. Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons. Brain Res 2002;955:253-9.
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Xiao AY, Wei L, Xia S, Rothman S, Yu SP. Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons. J Neurosci 2002;22:1350-62.
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Manzerra P, Behrens MM, Canzoniero LM, Wang XQ, Heidinger V, Ichinose T, Yu SP, Choi DW. Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proc Natl Acad Sci U S A 2001;98:11055-61.
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Xiao AY, Homma M, Wang XQ, Wang X, Yu SP. Role of K(+) efflux in apoptosis induced by AMPA and kainate in mouse cortical neurons. Neuroscience 2001;108:61-7.
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Yu SP, Canzoniero LM, Choi DW. Ion homeostasis and apoptosis. Curr Opin Cell Biol 2001;13:405-11.
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Brown BS, Yu SP. Modulation and genetic identification of the M channel. Prog Biophys Mol Biol 2000;73:135-66.
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Kerchner GA, Canzoniero LM, Yu SP, Ling C, Choi DW. Zn2+ current is mediated by voltage-gated Ca2+ channels and enhanced by extracellular acidity in mouse cortical neurones. J Physiol 2000;528 Pt 1:39-52.
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Snider BJ, Choi J, Turetsky DM, Canzoniero LM, Sensi SL, Sheline CT, Wang X, Yu SP, Choi DW. Nitric oxide reduces Ca(2+) and Zn(2+) influx through voltage-gated Ca(2+) channels and reduces Zn(2+) neurotoxicity. Neuroscience 2000;100:651-61.
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Wang X, Xiao AY, Ichinose T, Yu SP. Effects of tetraethylammonium analogs on apoptosis and membrane currents in cultured cortical neurons. J Pharmacol Exp Ther 2000;295:524-30.
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Yu SP, Choi DW. Ions, cell volume, and apoptosis. Proc Natl Acad Sci U S A 2000;97:9360-2. [ Full Text Article]
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Behrens MM, Strasser U, Heidinger V, Lobner D, Yu SP, McDonald JW, Won M, Choi DW. Selective activation of group II mGluRs with LY354740 does not prevent neuronal excitotoxicity. Neuropharmacology 1999;38:1621-30.
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Yu SP, Yeh C, Strasser U, Tian M, Choi DW. NMDA receptor-mediated K+ efflux and neuronal apoptosis. Science 1999;284:336-9.
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Yu SP, Yeh CH, Gottron F, Wang X, Grabb MC, Choi DW. Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons. J Neurochem 1999;73:933-41.
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Yu SP, Farhangrazi ZS, Ying HS, Yeh CH, Choi DW. Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death. Neurobiol Dis 1998;5:81-8.
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Yu SP, Kerchner GA. Endogenous voltage-gated potassium channels in human embryonic kidney (HEK293) cells. J Neurosci Res 1998;52:612-7.
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Sensi SL, Canzoniero LM, Yu SP, Ying HS, Koh JY, Kerchner GA, Choi DW. Measurement of intracellular free zinc in living cortical neurons: routes of entry. J Neurosci 1997;17:9554-64.
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Yu SP, Choi DW. Na(+)-Ca2+ exchange currents in cortical neurons: concomitant forward and reverse operation and effect of glutamate. Eur J Neurosci 1997;9:1273-81.
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Yu SP, Sensi SL, Canzoniero LM, Buisson A, Choi DW. Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons. J Physiol 1997;499 ( Pt 3):721-32.
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Yu SP, Yeh CH, Sensi SL, Gwag BJ, Canzoniero LM, Farhangrazi ZS, Ying HS, Tian M, Dugan LL, Choi DW. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 1997;278:114-7.
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Buisson A, Yu SP, Choi DW. DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons. Eur J Neurosci 1996;8:138-43.
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Dugan LL, Gabrielsen JK, Yu SP, Lin TS, Choi DW. Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons. Neurobiol Dis 1996;3:129-35.
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Gubitosi-Klug RA, Yu SP, Choi DW, Gross RW. Concomitant acceleration of the activation and inactivation kinetics of the human delayed rectifier K+ channel (Kv1.1) by Ca(2+)-independent phospholipase A2. J Biol Chem 1995;270:2885-8.
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Lynch JJ, 3rd, Yu SP, Canzoniero LM, Sensi SL, Choi DW. Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists. J Pharmacol Exp Ther 1995;273:554-60.
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Yu SP. Roles of arachidonic acid, lipoxygenases and phosphatases in calcium-dependent modulation of M-current in bullfrog sympathetic neurons. J Physiol 1995;487 ( Pt 3):797-811. [ Full Text Article]
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Csernansky CA, Canzoniero LM, Sensi SL, Yu SP, Choi DW. Delayed application of aurintricarboxylic acid reduces glutamate-induced cortical neuronal injury. J Neurosci Res 1994;38:101-8.
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Yu SP, O'Malley DM, Adams PR. Regulation of M current by intracellular calcium in bullfrog sympathetic ganglion neurons. J Neurosci 1994;14:3487-99.
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Yu SP, Van der Kloot W. Increasing quantal size at the mouse neuromuscular junction and the role of choline. J Physiol 1991;433:677-704.
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Yu SP, Van der Kloot W. Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine. Neurosci Lett 1990;117:111-6.
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Lupa MT, Tabti N, Thesleff S, Vyskocil F, Yu SP. The nature and origin of calcium-insensitive miniature end-plate potentials at rodent neuromuscular junctions. J Physiol 1986;381:607-18.
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Lupa MT, Yu SP. A comparison of miniature end-plate potentials at normal, denervated, and long-term botulinum toxin type A poisoned frog neuromuscular junctions. Pflugers Arch 1986;407:476-81.
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Tabti N, Lupa MT, Yu SP, Thesleff S. Pharmacological characterization of the calcium-insensitive, intermittent acetylcholine release at the rat neuromuscular junction. Acta Physiol Scand 1986;128:429-36.
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Yu SP, Liu CG. [Antagonism of non-depolarization muscle relaxants and aminoglycoside antibiotics to the block of neuromuscular junction of the rat diaphragm caused by soman]. Zhongguo Yao Li Xue Bao 1985;6:11-6.
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